Two sample MR report
HLA-DRB5_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | -0.2070536 | 0.0620372 | 0.0041753 |
| Weighted median | 18 | 0.0455029 | 0.0144087 | 0.0015885 |
| Inverse variance weighted | 18 | 0.0389000 | 0.0129017 | 0.0025689 |
| Simple mode | 18 | 0.0566979 | 0.0287399 | 0.0650079 |
| Weighted mode | 18 | 0.0566979 | 0.0324344 | 0.0984855 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 19.64903 | 16 | 0.2364458 |
| Inverse variance weighted | 39.40464 | 17 | 0.0015692 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1004637 | 0.0250481 | 0.0010088 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002628 | 0 | TRUE | 0.1271423 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
